N-[苄氧羰基]-L-缬氨酰基-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺氟甲基酮
Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE
CAS: 187389-52-2
Molecular Formula: C22H30FN3O7
N-[苄氧羰基]-L-缬氨酰基-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺氟甲基酮 - Names and Identifiers
N-[苄氧羰基]-L-缬氨酰基-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺氟甲基酮 - Physico-chemical Properties
| Molecular Formula | C22H30FN3O7 |
| Molar Mass | 467.49 |
| Density | 1.214±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | >190°C (dec.) |
| Boling Point | 732.4±60.0 °C(Predicted) |
| Flash Point | 396.7℃ |
| Solubility | DMSO: 20mg/mL |
| Appearance | powder |
| Color | white |
| pKa | 11.05±0.46(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week. |
| In vitro study | Z-VAD-FMK(10 mM) acted on THP.1 cells to inhibit apoptosis. Z-VAD-FMK(10 μm) acts on THP.1 cell lysate to inhibit activation of PARP protease activity. Z-VAD-FMK(10 mM) inhibits CPP32 processing in intact THP.1 and Jurkat cells. Z-VAD-FMK(50 μm) co-treatment of HL60 cells with Camptothecin abolished the apoptotic morphology of Camptothecin-treated cells. Z-VAD-FMK(50 μm) inhibits Camptothecin-induced DNA division in HL60 cells. Z-VAD-FMK (50 μm) increased the survival percentage of transfected cells from 26% to 63% in S2 cells. Z-VAD-FMK(>100 μm) acts on human neutrophils to enhance TNFα-induced neutrophil apoptosis, and lower concentrations (1-30 μm) completely inhibit TNFα-stimulated apoptosis. Z-VAD-FMK (10 mM) acts on early corneal stromal cells and inhibits apoptosis. |
| In vivo study | Studies have shown that the administration of Z-VAD-FMK in vivo is not toxic and can inhibit apoptosis in animal models. In mice, intraperitoneal injection of HK-GBS can cause preterm labor, while pretreatment with Z-VAD-FMK can delay the phenomenon of preterm labor. In OVA-sensitive mice, z-VAD-fmk treatment inhibited allergen-induced leukocyte infiltration. Systemic injection of z-VAD-fmk prior to OVA sensitization reduced the accumulation of inflammatory cells, mucus hypersecretion, and Th2 cytokine release in OVA-sensitive/challenged mice. Treatment with z-VAD-fmk prevents terminal differentiation of lens epithelial cells, keratinocytes; Differentiation of monocytes into macrophages; And differentiation of erythroid hematopoietic progenitors. z-VAD-fmk reduces allergen-induced airway inflammation and hypersensitivity, preventing subsequent T-cell activation. |
N-[苄氧羰基]-L-缬氨酰基-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺氟甲基酮 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29145090 |
N-[苄氧羰基]-L-缬氨酰基-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺氟甲基酮 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.139 ml | 10.695 ml | 21.391 ml |
| 5 mM | 0.428 ml | 2.139 ml | 4.278 ml |
| 10 mM | 0.214 ml | 1.07 ml | 2.139 ml |
| 5 mM | 0.043 ml | 0.214 ml | 0.428 ml |
Last Update：2024-01-02 23:10:35
N-[苄氧羰基]-L-缬氨酰基-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺氟甲基酮 - Reference Information
| biological activity | Z-VAD-FMK (Z-VAD(OH)-FMK) is a cell-permeable, irreversible, pan-caspase inhibitor, all properties of apoptosis were blocked in THP-1 and Jurkat T cells. |
| Target | Value |
Last Update：2024-04-09 21:01:54
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View History
N-[苄氧羰基]-L-缬氨酰基-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺氟甲基酮
八氢吡咯并[1,2-A]氮杂环辛(间)四稀-5(1H)-酮
Thalidomide-PEG4-NH2 (hydrochloride)
cis-4-morpholinocyclohexan-1-ol
FMOC-(3-氨基甲基苯基)乙酸
C.I. Reactive yellow 145
4-辛基噻吩-2-三丁基锡
4-三甲硅乙炔基苯甲醛
7,7-二氟-6-甲基双环[4.1.0]庚烷-3-羧酸乙酯
CLP ILM05.2 ICP-MS SPIKING SOLUTION
八氢吡咯并[1,2-A]氮杂环辛(间)四稀-5(1H)-酮
Thalidomide-PEG4-NH2 (hydrochloride)
cis-4-morpholinocyclohexan-1-ol
FMOC-(3-氨基甲基苯基)乙酸
C.I. Reactive yellow 145
4-辛基噻吩-2-三丁基锡
4-三甲硅乙炔基苯甲醛
7,7-二氟-6-甲基双环[4.1.0]庚烷-3-羧酸乙酯
CLP ILM05.2 ICP-MS SPIKING SOLUTION